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4cfg
From Proteopedia
(Difference between revisions)
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==Structure of the TRIM25 coiled-coil== | ==Structure of the TRIM25 coiled-coil== | ||
| - | <StructureSection load='4cfg' size='340' side='right' caption='[[4cfg]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='4cfg' size='340' side='right'caption='[[4cfg]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CFG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4cfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CFG FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://pdbe.org/4cfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cfg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://pdbe.org/4cfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cfg ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref> | [[http://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref> | ||
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| + | ==See Also== | ||
| + | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: James, L]] | [[Category: James, L]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 08:51, 20 March 2019
Structure of the TRIM25 coiled-coil
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