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3oqc

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Revision as of 10:53, 18 May 2022

Ubiquitin-fold modifier 1 Specific Protease, UfSP2

Structural highlights

3oqc is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[UFSP2_MOUSE] Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.^[1] ^[2]

Publication Abstract from PubMed

Ubiquitin-fold modifier 1 (Ufm1)-specific protease 2 (UfSP2) is a cysteine protease that is responsible for the release of Ufm1 from Ufm1-conjugated cellular proteins, as well as for the generation of mature Ufm1 from its precursor. The 2.6 A resolution crystal structure of mouse UfSP2 reveals that it is composed of two domains. The C-terminal catalytic domain is similar to UfSP1 with Cys(294), Asp(418), His(420), Tyr(282), and a regulatory loop participating in catalysis. The novel N-terminal domain shows a unique structure and plays a role in the recognition of its cellular substrate C20orf116 and thus in the recruitment of UfSP2 to the endoplasmic reticulum, where C20orf116 predominantly localizes. Mutagenesis studies were carried out to provide the structural basis for understanding the loss of catalytic activity observed in a recently identified UfSP2 mutation that is associated with an autosomal dominant form of hip dysplasia.

Structure of ubiquitin-fold modifier 1-specific protease UfSP2.,Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE J Biol Chem. 2011 Mar 25;286(12):10248-57. Epub 2011 Jan 12. PMID:21228277^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kang SH, Kim GR, Seong M, Baek SH, Seol JH, Bang OS, Ovaa H, Tatsumi K, Komatsu M, Tanaka K, Chung CH. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J Biol Chem. 2007 Feb 23;282(8):5256-62. Epub 2006 Dec 20. PMID:17182609 doi:http://dx.doi.org/M610590200
↑ Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. J Biol Chem. 2011 Mar 25;286(12):10248-57. Epub 2011 Jan 12. PMID:21228277 doi:http://dx.doi.org/10.1074/jbc.M110.172171
↑ Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. J Biol Chem. 2011 Mar 25;286(12):10248-57. Epub 2011 Jan 12. PMID:21228277 doi:http://dx.doi.org/10.1074/jbc.M110.172171

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3oqc"

@@ Line 1: / Line 1: @@
 ==Ubiquitin-fold modifier 1 Specific Protease, UfSP2==
-<StructureSection load='3oqc' size='340' side='right' caption='[[3oqc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='3oqc' size='340' side='right'caption='[[3oqc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3oqc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OQC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3oqc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OQC FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oqc OCA], [http://pdbe.org/3oqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oqc RCSB], [http://www.ebi.ac.uk/pdbsum/3oqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oqc ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oqc OCA], [https://pdbe.org/3oqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oqc RCSB], [https://www.ebi.ac.uk/pdbsum/3oqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oqc ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/UFSP2_MOUSE UFSP2_MOUSE]] Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.<ref>PMID:17182609</ref> <ref>PMID:21228277</ref>
+[[https://www.uniprot.org/uniprot/UFSP2_MOUSE UFSP2_MOUSE]] Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.<ref>PMID:17182609</ref> <ref>PMID:21228277</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Lk3 transgenic mice]]
 [[Category: Chung, C H]]

3oqc

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Revision as of 10:53, 18 May 2022

Ubiquitin-fold modifier 1 Specific Protease, UfSP2

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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