3n96
From Proteopedia
(Difference between revisions)
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==Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1== | ==Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1== | ||
| - | <StructureSection load='3n96' size='340' side='right' caption='[[3n96]], [[Resolution|resolution]] 2.75Å' scene=''> | + | <StructureSection load='3n96' size='340' side='right'caption='[[3n96]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3n96]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3n96]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N96 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr> |
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n93|3n93]], [[3n95|3n95]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3n93|3n93]], [[3n95|3n95]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRFR2 alpha ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRFR2 alpha ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n96 OCA], [https://pdbe.org/3n96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n96 RCSB], [https://www.ebi.ac.uk/pdbsum/3n96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n96 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/UCN1_HUMAN UCN1_HUMAN]] Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Pal, K]] | [[Category: Pal, K]] | ||
[[Category: Pioszak, A A]] | [[Category: Pioszak, A A]] | ||
Revision as of 06:57, 12 May 2022
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1
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