1kkh
From Proteopedia
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'''Crystal Structure of the Methanococcus jannaschii Mevalonate Kinase''' | '''Crystal Structure of the Methanococcus jannaschii Mevalonate Kinase''' | ||
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[[Category: Shipman, L W.]] | [[Category: Shipman, L W.]] | ||
[[Category: Yang, D.]] | [[Category: Yang, D.]] | ||
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| - | [[Category: | + | [[Category: Phosphate-binding loop]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:51:06 2008'' | |
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Revision as of 19:51, 2 May 2008
Crystal Structure of the Methanococcus jannaschii Mevalonate Kinase
Overview
The mevalonate-dependent pathway is used by many organisms to synthesize isopentenyl pyrophosphate, the building block for the biosynthesis of many biologically important compounds, including farnesyl pyrophosphate, dolichol, and many sterols. Mevalonate kinase (MVK) catalyzes a critical phosphoryl transfer step, producing mevalonate 5'-phosphate. The crystal structure of thermostable MVK from Methanococcus jannaschii has been determined at 2.4 A, revealing an overall fold similar to the homoserine kinase from M. jannaschii. In addition, the enzyme shows structural similarity with mevalonate 5-diphosphate decarboxylase and domain IV of elongation factor G. The active site of MVK is in the cleft between its N- and C-terminal domains. Several structural motifs conserved among species, including a phosphate-binding loop, have been found in this cavity. Asp(155), an invariant residue among MVK sequences, is located close to the putative phosphate-binding site and has been assumed to play the catalytic role. Analysis of the MVK model in the context of the other members of the GHMP kinase family offers the opportunity to understand both the mechanism of these enzymes and the structural details that may lead to the design of novel drugs.
About this Structure
1KKH is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Reference
Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily., Yang D, Shipman LW, Roessner CA, Scott AI, Sacchettini JC, J Biol Chem. 2002 Mar 15;277(11):9462-7. Epub 2001 Dec 19. PMID:11751891 Page seeded by OCA on Fri May 2 22:51:06 2008
