1aa7
From Proteopedia
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| - | [[Image:1aa7.gif|left|200px]]<br /> | + | [[Image:1aa7.gif|left|200px]]<br /><applet load="1aa7" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1aa7" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1aa7, resolution 2.08Å" /> | caption="1aa7, resolution 2.08Å" /> | ||
'''INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0'''<br /> | '''INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AA7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. | + | 1AA7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Known structural/functional Site: <scene name='pdbsite=S1:RNA-Binding Site'>S1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AA7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: virion budding]] | [[Category: virion budding]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:11:18 2007'' |
Revision as of 12:01, 18 December 2007
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INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0
Overview
Matrix protein (M1) of influenza virus is a bifunctional protein that, mediates the encapsidation of RNA-nucleoprotein cores into the membrane, envelope. It is therefore required that M1 binds both membrane and RNA, simultaneously. The X-ray crystal structure of the N-terminal portion of, type A influenza virus M1-amino acid residues 2-158-has been determined at, 2.08 A resolution at pH 4.0. The protein forms a dimer. A highly, positively charged region on the dimer surface is suitably positioned to, bind RNA while the hydrophobic surface opposite the RNA binding region may, be involved in interactions with the membrane. The membrane-binding, hydrophobic surface could be buried or exposed after a conformational, change.
About this Structure
1AA7 is a Single protein structure of sequence from Unidentified influenza virus. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1., Sha B, Luo M, Nat Struct Biol. 1997 Mar;4(3):239-44. PMID:9164466
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