3ssb

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==Structure of Insect Metalloproteinase Inhibitor in Complex with Thermolysin==
==Structure of Insect Metalloproteinase Inhibitor in Complex with Thermolysin==
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<StructureSection load='3ssb' size='340' side='right' caption='[[3ssb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3ssb' size='340' side='right'caption='[[3ssb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ssb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus] and [http://en.wikipedia.org/wiki/Galme Galme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SSB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ssb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus] and [https://en.wikipedia.org/wiki/Galme Galme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SSB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7137 GALME])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7137 GALME])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ssb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ssb OCA], [http://pdbe.org/3ssb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ssb RCSB], [http://www.ebi.ac.uk/pdbsum/3ssb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ssb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ssb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ssb OCA], [https://pdbe.org/3ssb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ssb RCSB], [https://www.ebi.ac.uk/pdbsum/3ssb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ssb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease. [[http://www.uniprot.org/uniprot/IMPI_GALME IMPI_GALME]] Inhibits thermolysin, bacillolysin and pseudolysin, B.polymyxa metalloprotease and human MMP1 and MMP3. No activity on trypsin or cysteine protease papain.<ref>PMID:15115439</ref> <ref>PMID:9738891</ref>
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[[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease. [[https://www.uniprot.org/uniprot/IMPI_GALME IMPI_GALME]] Inhibits thermolysin, bacillolysin and pseudolysin, B.polymyxa metalloprotease and human MMP1 and MMP3. No activity on trypsin or cysteine protease papain.<ref>PMID:15115439</ref> <ref>PMID:9738891</ref>
==See Also==
==See Also==
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*[[Thermolysin|Thermolysin]]
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*[[Thermolysin 3D structures|Thermolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Bacillus thermoproteolyticus]]
[[Category: Bacillus thermoproteolyticus]]
[[Category: Galme]]
[[Category: Galme]]
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[[Category: Large Structures]]
[[Category: Thermolysin]]
[[Category: Thermolysin]]
[[Category: Arolas, J L]]
[[Category: Arolas, J L]]

Revision as of 08:08, 29 June 2022

Structure of Insect Metalloproteinase Inhibitor in Complex with Thermolysin

PDB ID 3ssb

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