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4nbl

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==Tailoring Small Molecules for an Allosteric Site on Procaspase-6==
==Tailoring Small Molecules for an Allosteric Site on Procaspase-6==
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<StructureSection load='4nbl' size='340' side='right' caption='[[4nbl]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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<StructureSection load='4nbl' size='340' side='right'caption='[[4nbl]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NBL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NBL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2J6:5-FLUORO-2-({[3-(PYRIMIDIN-2-YL)PYRIDIN-2-YL]AMINO}METHYL)PHENOL'>2J6</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2J6:5-FLUORO-2-({[3-(PYRIMIDIN-2-YL)PYRIDIN-2-YL]AMINO}METHYL)PHENOL'>2J6</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n5d|4n5d]], [[4n6g|4n6g]], [[4n7m|4n7m]], [[4n7j|4n7j]], [[4nbk|4nbk]], [[4nbn|4nbn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nbl OCA], [https://pdbe.org/4nbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nbl RCSB], [https://www.ebi.ac.uk/pdbsum/4nbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nbl ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2, procaspase-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nbl OCA], [http://pdbe.org/4nbl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nbl RCSB], [http://www.ebi.ac.uk/pdbsum/4nbl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nbl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caspase-6]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Murray, J M]]
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[[Category: Murray JM]]
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[[Category: Steffek, M]]
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[[Category: Steffek M]]
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[[Category: Allosteric]]
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[[Category: Caspase]]
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[[Category: Caspase-6 zymogen]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Procaspse-6]]
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[[Category: Structure based drug design]]
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Revision as of 08:20, 11 January 2023

Tailoring Small Molecules for an Allosteric Site on Procaspase-6

PDB ID 4nbl

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