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1kq2

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[[Image:1kq2.gif|left|200px]]
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{{Structure
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|RELATEDENTRY=[[1kq1|1KQ1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kq2 OCA], [http://www.ebi.ac.uk/pdbsum/1kq2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kq2 RCSB]</span>
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'''Crystal Structure of an Hfq-RNA Complex'''
'''Crystal Structure of an Hfq-RNA Complex'''
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[[Category: Schumacher, M A.]]
[[Category: Schumacher, M A.]]
[[Category: Valentin-Hansen, P.]]
[[Category: Valentin-Hansen, P.]]
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[[Category: hfq-rna complex]]
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[[Category: Hfq-rna complex]]
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[[Category: single-stranded rna]]
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[[Category: Single-stranded rna]]
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[[Category: translational regulator]]
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[[Category: Translational regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:01:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:51:56 2008''
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Revision as of 20:02, 2 May 2008

Image:1kq2.gif

Template:STRUCTURE 1kq2

Crystal Structure of an Hfq-RNA Complex


Overview

In prokaryotes, Hfq regulates translation by modulating the structure of numerous RNA molecules by binding preferentially to A/U-rich sequences. To elucidate the mechanisms of target recognition and translation regulation by Hfq, we determined the crystal structures of the Staphylococcus aureus Hfq and an Hfq-RNA complex to 1.55 and 2.71 A resolution, respectively. The structures reveal that Hfq possesses the Sm-fold previously observed only in eukaryotes and archaea. However, unlike these heptameric Sm proteins, Hfq forms a homo-hexameric ring. The Hfq-RNA structure reveals that the single-stranded hepta-oligoribonucleotide binds in a circular conformation around a central basic cleft, whereby Tyr42 residues from adjacent subunits stack with six of the bases, and Gln8, outside the Sm motif, provides key protein-base contacts. Such binding suggests a mechanism for Hfq function.

About this Structure

1KQ2 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein., Schumacher MA, Pearson RF, Moller T, Valentin-Hansen P, Brennan RG, EMBO J. 2002 Jul 1;21(13):3546-56. PMID:12093755 Page seeded by OCA on Fri May 2 23:01:59 2008

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