4ngt

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==Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor==
==Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor==
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<StructureSection load='4ngt' size='340' side='right' caption='[[4ngt]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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<StructureSection load='4ngt' size='340' side='right'caption='[[4ngt]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ngt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NGT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ngt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NGT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=J42:N-{[(1S)-5-({[4-BROMO-2-({4,44-DIOXO-48-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]-7,10,13,16,19,22,25,28,31,34,37,40-DODECAOXA-3,43-DIAZAOCTATETRACONT-1-YL}OXY)PHENYL]CARBAMOYL}AMINO)-1-CARBOXYPENTYL]CARBAMOYL}-L-GLUTAMIC+ACID'>J42</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=J42:N-{[(1S)-5-({[4-bromo-2-({4,44-dioxo-48-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-3,43-diazaoctatetracont-1-yl}oxy)phenyl]carbamoyl}amino)-1-carboxypentyl]carbamoyl}-L-glutamic+acid'>J42</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d7h|3d7h]], [[4ngm|4ngm]], [[4ngn|4ngn]], [[4ngp|4ngp]], [[4ngq|4ngq]], [[4ngr|4ngr]], [[4ngs|4ngs]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d7h|3d7h]], [[4ngm|4ngm]], [[4ngn|4ngn]], [[4ngp|4ngp]], [[4ngq|4ngq]], [[4ngr|4ngr]], [[4ngs|4ngs]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOLH, FOLH1, GIG27, NAALAD1, PSM, PSMA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ngt OCA], [http://pdbe.org/4ngt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ngt RCSB], [http://www.ebi.ac.uk/pdbsum/4ngt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ngt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ngt OCA], [http://pdbe.org/4ngt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ngt RCSB], [http://www.ebi.ac.uk/pdbsum/4ngt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ngt ProSAT]</span></td></tr>
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</StructureSection>
</StructureSection>
[[Category: Glutamate carboxypeptidase II]]
[[Category: Glutamate carboxypeptidase II]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Pachl, P]]
[[Category: Pachl, P]]
[[Category: Tykvart, J]]
[[Category: Tykvart, J]]

Revision as of 08:19, 10 April 2019

Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor

PDB ID 4ngt

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