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4gpo

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Revision as of 07:09, 26 October 2022

Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor

Structural highlights

4gpo is a 2 chain structure with sequence from Meleagris gallopavo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADRB1_MELGA Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

Publication Abstract from PubMed

G protein-coupled receptors (GPCRs) mediate transmembrane signaling. Before ligand binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with antagonists or agonists have been solved. However, the crystal structure of the ligand-free basal state of a GPCR, the starting point of GPCR activation and function, had not yet been determined. Here we report the X-ray crystal structure of the ligand-free basal state of a GPCR in a lipid membrane-like environment. Oligomeric turkey beta1-adrenergic receptors display two dimer interfaces. One interface involves the transmembrane domain (TM) 1, TM2, the C-terminal H8 and extracellular loop 1. The other interface engages residues from TM4, TM5, intracellular loop 2 and extracellular loop 2. Structural comparisons show that this ligand-free state is in an inactive conformation. This provides the structural basis of GPCR dimerization and oligomerization.

Crystal structure of oligomeric beta1-adrenergic G protein-coupled receptors in ligand-free basal state.,Huang J, Chen S, Zhang JJ, Huang XY Nat Struct Mol Biol. 2013 Apr;20(4):419-25. doi: 10.1038/nsmb.2504. Epub 2013 Feb, 24. PMID:23435379^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Huang J, Chen S, Zhang JJ, Huang XY. Crystal structure of oligomeric beta1-adrenergic G protein-coupled receptors in ligand-free basal state. Nat Struct Mol Biol. 2013 Apr;20(4):419-25. doi: 10.1038/nsmb.2504. Epub 2013 Feb, 24. PMID:23435379 doi:10.1038/nsmb.2504

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4gpo"

@@ Line 1: / Line 1: @@
 ==Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor==
-<StructureSection load='4gpo' size='340' side='right' caption='[[4gpo]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
+<StructureSection load='4gpo' size='340' side='right'caption='[[4gpo]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4gpo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_turkey Common turkey]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GPO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4gpo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GPO FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9103 Common turkey])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gpo OCA], [https://pdbe.org/4gpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gpo RCSB], [https://www.ebi.ac.uk/pdbsum/4gpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gpo ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gpo OCA], [http://pdbe.org/4gpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gpo RCSB], [http://www.ebi.ac.uk/pdbsum/4gpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gpo ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
+[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 19: @@
 ==See Also==
-*[[Adrenergic receptor|Adrenergic receptor]]
+*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Common turkey]]
+[[Category: Large Structures]]
-[[Category: Chen, S]]
+[[Category: Meleagris gallopavo]]
-[[Category: Huang, J J]]
+[[Category: Chen S]]
-[[Category: Huang, X Y]]
+[[Category: Huang JJ]]
-[[Category: Zhang, J J]]
+[[Category: Huang XY]]
-[[Category: G-protein coupled receptor]]
+[[Category: Zhang JJ]]
-[[Category: Receptor]]
-[[Category: Seven-transmembrane helix receptor]]

4gpo

From Proteopedia

Revision as of 07:09, 26 October 2022

Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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