1ktq

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[[Image:1ktq.jpg|left|200px]]
[[Image:1ktq.jpg|left|200px]]
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{{Structure
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|PDB= 1ktq |SIZE=350|CAPTION= <scene name='initialview01'>1ktq</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1ktq", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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{{STRUCTURE_1ktq| PDB=1ktq | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktq OCA], [http://www.ebi.ac.uk/pdbsum/1ktq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ktq RCSB]</span>
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'''DNA POLYMERASE'''
'''DNA POLYMERASE'''
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[[Category: Korolev, S.]]
[[Category: Korolev, S.]]
[[Category: Waksman, G.]]
[[Category: Waksman, G.]]
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[[Category: dna-replication]]
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[[Category: Dna-replication]]
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[[Category: nucleotidyltransferase]]
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[[Category: Nucleotidyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:09:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:53:27 2008''
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Revision as of 20:09, 2 May 2008

Image:1ktq.jpg

Template:STRUCTURE 1ktq

DNA POLYMERASE


Overview

The crystal structure of the large fragment of the Thermus aquaticus DNA polymerase (Klentaq1), determined at 2.5-A resolution, demonstrates a compact two-domain architecture. The C-terminal domain is identical in fold to the equivalent region of the Klenow fragment of Escherichia coli DNA polymerase I (Klenow pol I). Although the N-terminal domain of Klentaq1 differs greatly in sequence from its counterpart in Klenow pol I, it has clearly evolved from a common ancestor. The structure of Klentaq1 reveals the strategy utilized by this protein to maintain activity at high temperatures and provides the structural basis for future improvements of the enzyme.

About this Structure

1KTQ is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability., Korolev S, Nayal M, Barnes WM, Di Cera E, Waksman G, Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9264-8. PMID:7568114 Page seeded by OCA on Fri May 2 23:09:40 2008

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