4g35

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==Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.==
==Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.==
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<StructureSection load='4g35' size='340' side='right' caption='[[4g35]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4g35' size='340' side='right'caption='[[4g35]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G35 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G35 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4BP:4,4-BIS(BROMOMETHYL)BIPHENYL'>4BP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4BP:4,4-BIS(BROMOMETHYL)BIPHENYL'>4BP</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [https://pdbe.org/4g35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [https://www.ebi.ac.uk/pdbsum/4g35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g35 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mcl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g35 OCA], [http://pdbe.org/4g35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g35 RCSB], [http://www.ebi.ac.uk/pdbsum/4g35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g35 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
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[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4g35" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4g35" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Drake, E]]
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[[Category: Mus musculus]]
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[[Category: Edwardraja, S]]
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[[Category: Drake E]]
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[[Category: Gulick, A M]]
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[[Category: Edwardraja S]]
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[[Category: Lin, Q]]
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[[Category: Gulick AM]]
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[[Category: Apoptosis]]
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[[Category: Lin Q]]
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[[Category: Apoptosis-inhibitor complex]]
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[[Category: Bcl-2 family]]
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[[Category: Bh3 domain]]
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Revision as of 20:22, 19 October 2022

Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.

PDB ID 4g35

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