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3g7t
From Proteopedia
(Difference between revisions)
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==Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation== | ==Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation== | ||
| - | <StructureSection load='3g7t' size='340' side='right' caption='[[3g7t]], [[Resolution|resolution]] 3.50Å' scene=''> | + | <StructureSection load='3g7t' size='340' side='right'caption='[[3g7t]], [[Resolution|resolution]] 3.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3g7t]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3g7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G7T FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11053 Dengue virus 1])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g7t OCA], [https://pdbe.org/3g7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g7t RCSB], [https://www.ebi.ac.uk/pdbsum/3g7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g7t ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/Q5USP2_9FLAV Q5USP2_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Dengue virus 1]] | [[Category: Dengue virus 1]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Modis, Y]] | [[Category: Modis, Y]] | ||
[[Category: Beta sandwich]] | [[Category: Beta sandwich]] | ||
Revision as of 07:57, 9 March 2022
Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation
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