4egl
From Proteopedia
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==Crystal structure of two tandem RNA recognition motifs of Human antigen R== | ==Crystal structure of two tandem RNA recognition motifs of Human antigen R== | ||
| - | <StructureSection load='4egl' size='340' side='right' caption='[[4egl]], [[Resolution|resolution]] 2.90Å' scene=''> | + | <StructureSection load='4egl' size='340' side='right'caption='[[4egl]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4egl]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4egl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGL FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4egl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egl OCA], [https://pdbe.org/4egl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4egl RCSB], [https://www.ebi.ac.uk/pdbsum/4egl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4egl ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN]] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Li | + | [[Category: Large Structures]] |
| - | [[Category: Liu | + | [[Category: Li X]] |
| - | [[Category: Teng | + | [[Category: Liu H]] |
| - | [[Category: Wang | + | [[Category: Teng M]] |
| - | [[Category: Zeng | + | [[Category: Wang H]] |
| - | + | [[Category: Zeng F]] | |
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Revision as of 07:10, 28 September 2022
Crystal structure of two tandem RNA recognition motifs of Human antigen R
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Categories: Homo sapiens | Large Structures | Li X | Liu H | Teng M | Wang H | Zeng F
