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4f2p

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==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A==
==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A==
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<StructureSection load='4f2p' size='340' side='right' caption='[[4f2p]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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<StructureSection load='4f2p' size='340' side='right'caption='[[4f2p]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4f2p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_choleraesuis_str._a50 Salmonella enterica subsp. enterica serovar choleraesuis str. a50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F2P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4f2p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Choleraesuis_str._SCSA50 Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EL:(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-({[2-(2-HYDROXYETHOXY)ETHYL]SULFANYL}METHYL)PYRROLIDIN-3-OL'>2EL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2EL:(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-({[2-(2-HYDROXYETHOXY)ETHYL]SULFANYL}METHYL)PYRROLIDIN-3-OL'>2EL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f1w|4f1w]], [[4f2w|4f2w]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2p OCA], [https://pdbe.org/4f2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2p RCSB], [https://www.ebi.ac.uk/pdbsum/4f2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2p ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EMBL EFZ04802.1, mtnN, pfs, SCA50_0219, SCH_0207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=904139 Salmonella enterica subsp. enterica serovar Choleraesuis str. A50])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2p OCA], [http://pdbe.org/4f2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f2p RCSB], [http://www.ebi.ac.uk/pdbsum/4f2p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2p ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/E8NLP5_SALET E8NLP5_SALET]] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity).[HAMAP-Rule:MF_01684]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenosylhomocysteine nucleosidase]]
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar choleraesuis str. a50]]
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[[Category: Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Bonanno, J B]]
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[[Category: Bonanno JB]]
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[[Category: Haapalainen, A M]]
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[[Category: Haapalainen AM]]
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[[Category: Schramm, V L]]
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[[Category: Schramm VL]]
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[[Category: Thomas, K]]
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[[Category: Thomas K]]
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[[Category: 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase]]
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[[Category: Acting on glycosyl bond]]
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[[Category: Adenosylhomocysteine nucleosidase activity]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: L-methionine biosynthetic process from s-adenosylmethionine]]
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[[Category: L-methionine salvage from methylthioadenosine]]
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[[Category: Methylthioadenosine nucleosidase activity]]
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Revision as of 04:30, 7 October 2022

Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A

PDB ID 4f2p

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