1kxl
From Proteopedia
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[[Image:1kxl.gif|left|200px]] | [[Image:1kxl.gif|left|200px]] | ||
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'''Solution Structure of the Cdc13 DNA-binding Domain in a Complex with Single-Stranded Telomeric DNA (DNA structure not modeled)''' | '''Solution Structure of the Cdc13 DNA-binding Domain in a Complex with Single-Stranded Telomeric DNA (DNA structure not modeled)''' | ||
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[[Category: Mitton-Fry, R M.]] | [[Category: Mitton-Fry, R M.]] | ||
[[Category: Wuttke, D S.]] | [[Category: Wuttke, D S.]] | ||
| - | [[Category: | + | [[Category: Dna-binding domain]] |
| - | [[Category: | + | [[Category: Ob fold]] |
| - | [[Category: | + | [[Category: Single-stranded dna]] |
| - | [[Category: | + | [[Category: Telomere]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:17:43 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:17, 2 May 2008
Solution Structure of the Cdc13 DNA-binding Domain in a Complex with Single-Stranded Telomeric DNA (DNA structure not modeled)
Overview
The essential Cdc13 protein in the yeast Saccharomyces cerevisiae is a single-stranded telomeric DNA binding protein required for chromosome end protection and telomere replication. Here we report the solution structure of the Cdc13 DNA binding domain in complex with telomeric DNA. The structure reveals the use of a single OB (oligonucleotide/oligosaccharide binding) fold augmented by an unusually large loop for DNA recognition. This OB fold is structurally similar to OB folds found in the ciliated protozoan telomere end-binding protein, although no sequence similarity is apparent between them. The common usage of an OB fold for telomeric DNA interaction demonstrates conservation of end-protection mechanisms among eukaryotes.
About this Structure
1KXL is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Conserved structure for single-stranded telomeric DNA recognition., Mitton-Fry RM, Anderson EM, Hughes TR, Lundblad V, Wuttke DS, Science. 2002 Apr 5;296(5565):145-7. PMID:11935027 Page seeded by OCA on Fri May 2 23:17:43 2008
