1ky3

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[[Image:1ky3.jpg|left|200px]]
[[Image:1ky3.jpg|left|200px]]
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{{Structure
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|PDB= 1ky3 |SIZE=350|CAPTION= <scene name='initialview01'>1ky3</scene>, resolution 1.35&Aring;
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The line below this paragraph, containing "STRUCTURE_1ky3", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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|GENE= ypt7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_1ky3| PDB=1ky3 | SCENE= }}
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|RELATEDENTRY=[[1ky2|1KY2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ky3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ky3 OCA], [http://www.ebi.ac.uk/pdbsum/1ky3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ky3 RCSB]</span>
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'''GDP-BOUND YPT7P AT 1.35 A RESOLUTION'''
'''GDP-BOUND YPT7P AT 1.35 A RESOLUTION'''
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[[Category: Rak, A.]]
[[Category: Rak, A.]]
[[Category: Scheidig, A J.]]
[[Category: Scheidig, A J.]]
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[[Category: endocytosis]]
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[[Category: Endocytosis]]
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[[Category: g protein]]
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[[Category: G protein]]
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[[Category: gtp hydrolysis]]
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[[Category: Gtp hydrolysis]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: vesicular traffic]]
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[[Category: Vesicular traffic]]
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[[Category: ypt/rab protein]]
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[[Category: Ypt/rab protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:18:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:55:18 2008''
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Revision as of 20:18, 2 May 2008

Image:1ky3.jpg

Template:STRUCTURE 1ky3

GDP-BOUND YPT7P AT 1.35 A RESOLUTION


Overview

The GTPase Ypt7p from S. cerevisiae is involved in late endosome-to-vacuole transport and homotypic vacuole fusion. We present crystal structures of the GDP- and GppNHp-bound conformation of Ypt7p solved at 1.35 and 1.6 A resolution, respectively. Despite the similarity of the overall structure to other Ypt/Rab proteins, Ypt7p displays small but significant differences. The Ypt7p-specific residues Tyr33 and Tyr37 cause a difference in the main chain trace of the RabSF2 region and form a characteristic surface epitope. Ypt7p*GppNHp does not display the helix alpha2, characteristic of the Ras-superfamily, but instead possess an extended loop L4/L5. Due to insertions in loops L3 and L7, the neighboring RabSF1 and RabSF4 regions are different in their conformations to those of other Ypt/Rab proteins.

About this Structure

1KY3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases., Constantinescu AT, Rak A, Alexandrov K, Esters H, Goody RS, Scheidig AJ, Structure. 2002 Apr;10(4):569-79. PMID:11937061 Page seeded by OCA on Fri May 2 23:18:48 2008

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