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1ky3
From Proteopedia
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[[Image:1ky3.jpg|left|200px]] | [[Image:1ky3.jpg|left|200px]] | ||
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'''GDP-BOUND YPT7P AT 1.35 A RESOLUTION''' | '''GDP-BOUND YPT7P AT 1.35 A RESOLUTION''' | ||
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[[Category: Rak, A.]] | [[Category: Rak, A.]] | ||
[[Category: Scheidig, A J.]] | [[Category: Scheidig, A J.]] | ||
| - | [[Category: | + | [[Category: Endocytosis]] |
| - | [[Category: | + | [[Category: G protein]] |
| - | [[Category: | + | [[Category: Gtp hydrolysis]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Vesicular traffic]] |
| - | [[Category: | + | [[Category: Ypt/rab protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:18:48 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:18, 2 May 2008
GDP-BOUND YPT7P AT 1.35 A RESOLUTION
Overview
The GTPase Ypt7p from S. cerevisiae is involved in late endosome-to-vacuole transport and homotypic vacuole fusion. We present crystal structures of the GDP- and GppNHp-bound conformation of Ypt7p solved at 1.35 and 1.6 A resolution, respectively. Despite the similarity of the overall structure to other Ypt/Rab proteins, Ypt7p displays small but significant differences. The Ypt7p-specific residues Tyr33 and Tyr37 cause a difference in the main chain trace of the RabSF2 region and form a characteristic surface epitope. Ypt7p*GppNHp does not display the helix alpha2, characteristic of the Ras-superfamily, but instead possess an extended loop L4/L5. Due to insertions in loops L3 and L7, the neighboring RabSF1 and RabSF4 regions are different in their conformations to those of other Ypt/Rab proteins.
About this Structure
1KY3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases., Constantinescu AT, Rak A, Alexandrov K, Esters H, Goody RS, Scheidig AJ, Structure. 2002 Apr;10(4):569-79. PMID:11937061 Page seeded by OCA on Fri May 2 23:18:48 2008
