1ky7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ky7.gif|left|200px]]
[[Image:1ky7.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ky7 |SIZE=350|CAPTION= <scene name='initialview01'>1ky7</scene>, resolution 2.15&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ky7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ky7| PDB=1ky7 | SCENE= }}
-
|RELATEDENTRY=[[1qtp|1QTP]], [[1qts|1QTS]], [[1ky6|1KY6]], [[1ky7|1KY7]], [[1kyd|1KYD]], [[1kyf|1KYF]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ky7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ky7 OCA], [http://www.ebi.ac.uk/pdbsum/1ky7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ky7 RCSB]</span>
+
-
}}
+
'''THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF'''
'''THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF'''
Line 29: Line 26:
[[Category: Fremont, D H.]]
[[Category: Fremont, D H.]]
[[Category: Traub, L M.]]
[[Category: Traub, L M.]]
-
[[Category: endocytosis]]
+
[[Category: Endocytosis]]
-
[[Category: protein-peptide complex]]
+
[[Category: Protein-peptide complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:19:07 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:55:19 2008''
+

Revision as of 20:19, 2 May 2008

Image:1ky7.gif

Template:STRUCTURE 1ky7

THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF


Overview

Clathrin-mediated endocytosis depends upon the interaction of accessory proteins with the alpha-ear of the AP-2 adaptor. We present structural characterization of these regulatory interactions. DPF and DPW motif peptides derived from eps15 and epsin bind in type I beta turn conformations to a conserved pocket on the alpha-ear platform. We show evidence for a second binding site that is DPW motif specific. The structure of a complex with an AP-2 binding segment from amphiphysin reveals a novel binding motif that we term FxDxF, which is engaged in an extended conformation by a unique surface of the platform domain. The FxDxF motif is also used by AP180 and the 170 kDa isoform of synaptojanin and can be found in several potential endocytic proteins, including HIP1, CD2AP, and PLAP. A mechanism of clathrin assembly regulation is suggested by three different AP-2 engagement modes.

About this Structure

1KY7 is a Protein complex structure of sequences from Mus musculus. The following page contains interesting information on the relation of 1KY7 with [Clathrin]. Full crystallographic information is available from OCA.

Reference

Accessory protein recruitment motifs in clathrin-mediated endocytosis., Brett TJ, Traub LM, Fremont DH, Structure. 2002 Jun;10(6):797-809. PMID:12057195 Page seeded by OCA on Fri May 2 23:19:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ky7"
Personal tools