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4gaz
From Proteopedia
(Difference between revisions)
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==Crystal Structure of a Jumonji Domain-containing Protein JMJD5== | ==Crystal Structure of a Jumonji Domain-containing Protein JMJD5== | ||
| - | <StructureSection load='4gaz' size='340' side='right' caption='[[4gaz]], [[Resolution|resolution]] 2.81Å' scene=''> | + | <StructureSection load='4gaz' size='340' side='right'caption='[[4gaz]], [[Resolution|resolution]] 2.81Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4gaz]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4gaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAZ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaz OCA], [https://pdbe.org/4gaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gaz RCSB], [https://www.ebi.ac.uk/pdbsum/4gaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaz ProSAT]</span></td></tr> | |
| - | + | ||
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. |
==See Also== | ==See Also== | ||
| - | *[[Jumonji domain-containing protein|Jumonji domain-containing protein]] | + | *[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Chen | + | [[Category: Large Structures]] |
| - | [[Category: Tao | + | [[Category: Chen N]] |
| - | [[Category: Wang | + | [[Category: Tao Y]] |
| - | [[Category: Zang | + | [[Category: Wang H]] |
| - | [[Category: Zhang | + | [[Category: Zang J]] |
| - | [[Category: Zhou | + | [[Category: Zhang X]] |
| - | + | [[Category: Zhou X]] | |
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Current revision
Crystal Structure of a Jumonji Domain-containing Protein JMJD5
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Categories: Homo sapiens | Large Structures | Chen N | Tao Y | Wang H | Zang J | Zhang X | Zhou X
