1kzq
From Proteopedia
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'''crystal structure of a parasite protein''' | '''crystal structure of a parasite protein''' | ||
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[[Category: Grigg, M E.]] | [[Category: Grigg, M E.]] | ||
[[Category: He, X.]] | [[Category: He, X.]] | ||
| - | [[Category: | + | [[Category: Crystal structure]] |
| - | [[Category: | + | [[Category: Mad]] |
| - | [[Category: | + | [[Category: Major surface antigen]] |
| - | [[Category: | + | [[Category: Parasite invasion]] |
| - | [[Category: | + | [[Category: Sag1]] |
| - | [[Category: | + | [[Category: Toxoplasma gondii]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:22:34 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:22, 2 May 2008
crystal structure of a parasite protein
Overview
Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The 1.7 A structure of the immunodominant SAG1 antigen reveals a homodimeric configuration in which the dimeric interface is mediated by an extended beta-sheet that forms a deep groove lined with positively charged amino acids. This basic groove seems to be conserved among SRS proteins and potentially serves as a sulfated proteoglycan-binding site on target cell surfaces, thus rationalizing the promiscuous attachment properties of Toxoplasma to a broad range of host cell types.
About this Structure
1KZQ is a Single protein structure of sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.
Reference
Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily., He XL, Grigg ME, Boothroyd JC, Garcia KC, Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:12091874 Page seeded by OCA on Fri May 2 23:22:34 2008
