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3p9g
From Proteopedia
(Difference between revisions)
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==Crystal structure of the TSG101 UEV domain in complex with FA459 peptide== | ==Crystal structure of the TSG101 UEV domain in complex with FA459 peptide== | ||
| - | <StructureSection load='3p9g' size='340' side='right' caption='[[3p9g]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='3p9g' size='340' side='right'caption='[[3p9g]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3p9g]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3p9g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P9G FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZYK:(4R)-4-({[(3,4-DIMETHOXYPHENYL)CARBONYL]AMINO}OXY)-L-PROLINE'>ZYK</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZYK:(4R)-4-({[(3,4-DIMETHOXYPHENYL)CARBONYL]AMINO}OXY)-L-PROLINE'>ZYK</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3obq|3obq]], [[3p9h|3p9h]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3obq|3obq]], [[3p9h|3p9h]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSG101 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSG101 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p9g OCA], [https://pdbe.org/3p9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p9g RCSB], [https://www.ebi.ac.uk/pdbsum/3p9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p9g ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> [[https://www.uniprot.org/uniprot/Q9YP46_9HIV1 Q9YP46_9HIV1]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS012344_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS012344_004_011858] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Gag polyprotein|Gag polyprotein]] | ||
*[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]] | *[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]] | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hurley, J H]] | [[Category: Hurley, J H]] | ||
[[Category: Im, Y J]] | [[Category: Im, Y J]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Ubiquitin]] | [[Category: Ubiquitin]] | ||
Revision as of 08:30, 25 May 2022
Crystal structure of the TSG101 UEV domain in complex with FA459 peptide
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