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1l2q

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[[Image:1l2q.jpg|left|200px]]
[[Image:1l2q.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1l2q", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC+ACID'>BGX</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=X7O:5-AMINO-3-METHYL-PYRROLIDINE-2-CARBOXYLIC+ACID'>X7O</scene>
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{{STRUCTURE_1l2q| PDB=1l2q | SCENE= }}
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|RELATEDENTRY=[[1l2r|1L2R]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2q OCA], [http://www.ebi.ac.uk/pdbsum/1l2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l2q RCSB]</span>
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'''Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)'''
'''Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)'''
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[[Category: James, C M.]]
[[Category: James, C M.]]
[[Category: Krzycki, J A.]]
[[Category: Krzycki, J A.]]
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[[Category: tim barrel]]
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[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:28:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:57:08 2008''
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Revision as of 20:28, 2 May 2008

Image:1l2q.jpg

Template:STRUCTURE 1l2q

Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)


Overview

Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.

About this Structure

1L2Q is a Single protein structure of sequence from Methanosarcina barkeri. Full crystallographic information is available from OCA.

Reference

A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:12029132 Page seeded by OCA on Fri May 2 23:28:29 2008

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