2ydu

Publication Abstract from PubMed

Isothiazolidinone (IZD) heterocycles can act as effective components of protein tyrosine phosphatase (PTP) inhibitors by simultaneously replicating the binding interactions of both a phosphoryl group and a highly conserved water molecule, as exemplified by the structures of several PTP1B-inhibitor complexes. In the first unambiguous demonstration of IZD interactions with a PTP other than PTP1B, it is shown by X-ray crystallography that the IZD motif binds within the catalytic site of the Yersinia pestis PTP YopH by similarly displacing a highly conserved water molecule. It is also shown that IZD-based bidentate ligands can inhibit YopH in a nonpromiscuous fashion at low micromolar concentrations. Hence, the IZD moiety may represent a useful starting point for the development of YopH inhibitors.

Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH.,Kim SE, Bahta M, Lountos GT, Ulrich RG, Burke TR Jr, Waugh DS Acta Crystallogr D Biol Crystallogr. 2011 Jul;67(Pt 7):639-45. doi:, 10.1107/S0907444911018610. Epub 2011 Jun 11. PMID:21697602^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.