1l4a

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[[Image:1l4a.gif|left|200px]]
[[Image:1l4a.gif|left|200px]]
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{{Structure
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|PDB= 1l4a |SIZE=350|CAPTION= <scene name='initialview01'>1l4a</scene>, resolution 2.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1l4a", creates the "Structure Box" on the page.
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{{STRUCTURE_1l4a| PDB=1l4a | SCENE= }}
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|RELATEDENTRY=[[1sfc|1SFC]], [[1kil|1KIL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4a OCA], [http://www.ebi.ac.uk/pdbsum/1l4a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l4a RCSB]</span>
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'''X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI'''
'''X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI'''
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[[Category: Kadlec, J.]]
[[Category: Kadlec, J.]]
[[Category: Weissenhorn, W.]]
[[Category: Weissenhorn, W.]]
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[[Category: membrane fusion]]
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[[Category: Membrane fusion]]
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[[Category: neurotransmission]]
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[[Category: Neurotransmission]]
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[[Category: snare]]
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[[Category: Snare]]
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[[Category: snare complex]]
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[[Category: Snare complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:31:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:57:52 2008''
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Revision as of 20:31, 2 May 2008

Image:1l4a.gif

Template:STRUCTURE 1l4a

X-RAY STRUCTURE OF THE NEURONAL COMPLEXIN/SNARE COMPLEX FROM THE SQUID LOLIGO PEALEI


Overview

Nerve terminals release neurotransmitters from vesicles into the synaptic cleft upon transient increases in intracellular Ca(2+). This exocytotic process requires the formation of trans SNARE complexes and is regulated by accessory proteins including the complexins. Here we report the crystal structure of a squid core complexin-SNARE complex at 2.95-A resolution. A helical segment of complexin binds in anti-parallel fashion to the four-helix bundle of the core SNARE complex and interacts at its C terminus with syntaxin and synaptobrevin around the ionic zero layer of the SNARE complex. We propose that this structure is part of a multiprotein fusion machinery that regulates vesicle fusion at a late pre-fusion stage. Accordingly, Ca(2+) may initiate membrane fusion by acting directly or indirectly on complexin, thus allowing the conformational transitions of the trans SNARE complex that are thought to drive membrane fusion.

About this Structure

1L4A is a Protein complex structure of sequences from Loligo pealei. Full crystallographic information is available from OCA.

Reference

X-ray structure of a neuronal complexin-SNARE complex from squid., Bracher A, Kadlec J, Betz H, Weissenhorn W, J Biol Chem. 2002 Jul 19;277(29):26517-23. Epub 2002 May 9. PMID:12004067 Page seeded by OCA on Fri May 2 23:31:38 2008

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