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3oq3
From Proteopedia
(Difference between revisions)
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==Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor== | ==Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor== | ||
| - | <StructureSection load='3oq3' size='340' side='right' caption='[[3oq3]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='3oq3' size='340' side='right'caption='[[3oq3]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3oq3]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3oq3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ectv Ectv] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OQ3 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ifna5 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ifna5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), C12R, EVM166 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=265874 ECTV])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oq3 OCA], [https://pdbe.org/3oq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oq3 RCSB], [https://www.ebi.ac.uk/pdbsum/3oq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oq3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IFNA5_MOUSE IFNA5_MOUSE]] Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. |
==See Also== | ==See Also== | ||
| - | *[[Interferon|Interferon]] | + | *[[Interferon 3D structures|Interferon 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Ectv]] | [[Category: Ectv]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
Revision as of 10:52, 18 May 2022
Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor
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Categories: Ectv | Large Structures | Lk3 transgenic mice | Structural genomic | Fremont, D H | Lee, C A | Csgid | Cytokine decoy receptor | Cytokine-viral protein complex | Ectromelia | Extracellular | Ifn-alpha | Ifn-alpha/beta binding protein | Immunoglobulin domain | Immunoglobulin-like | Moscow strain | Mousepox virus | Secreted | Soluble a/b-ifnr | Type-1 interferon | Viral immune evasion | Virus/viral protein
