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| | ==Crystal Structure of PCNA from Drosophila melanogaster== | | ==Crystal Structure of PCNA from Drosophila melanogaster== |
| - | <StructureSection load='4hk1' size='340' side='right' caption='[[4hk1]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='4hk1' size='340' side='right'caption='[[4hk1]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4hk1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HK1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4hk1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HK1 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mus209, PCNA, CG9193 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk1 OCA], [https://pdbe.org/4hk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hk1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hk1 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk1 OCA], [http://pdbe.org/4hk1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hk1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hk1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hk1 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PCNA_DROME PCNA_DROME]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. | + | [https://www.uniprot.org/uniprot/PCNA_DROME PCNA_DROME] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | ==See Also== | | ==See Also== |
| - | *[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]] | + | *[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Drome]] | + | [[Category: Drosophila melanogaster]] |
| - | [[Category: Shi, Z B]] | + | [[Category: Large Structures]] |
| - | [[Category: Wang, K]] | + | [[Category: Shi ZB]] |
| - | [[Category: Zhou, Z C]] | + | [[Category: Wang K]] |
| - | [[Category: Cell cycle]] | + | [[Category: Zhou ZC]] |
| - | [[Category: Cell cycle control]]
| + | |
| - | [[Category: Dna binding]]
| + | |
| - | [[Category: Dna binding protein]]
| + | |
| - | [[Category: Dna repair]]
| + | |
| - | [[Category: Dna replication]]
| + | |
| Structural highlights
Function
PCNA_DROME This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Publication Abstract from PubMed
Proliferating cell nuclear antigen (PCNA) plays essential roles in DNA replication, DNA repair, cell-cycle regulation and chromatin metabolism. The PCNA from Drosophila melanogaster (DmPCNA) was purified and crystallized. The crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A. The structure of DmPCNA was determined by molecular replacement. DmPCNA forms a symmetric homotrimer in a head-to-tail manner. An interdomain connector loop (IDCL) links the N- and C-terminal domains. Additionally, the N-terminal and C-terminal domains contact each other through hydrophobic associations. Compared with human PCNA, the IDCL of DmPCNA has conformational changes, which may explain their difference in function. This work provides a structural basis for further functional and evolutionary studies of PCNA.
Structure of PCNA from Drosophila melanogaster.,Wang K, Shi Z, Zhang M, Cheng D Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):387-92., doi: 10.1107/S1744309113004971. Epub 2013 Mar 28. PMID:23545643[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Wang K, Shi Z, Zhang M, Cheng D. Structure of PCNA from Drosophila melanogaster. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):387-92., doi: 10.1107/S1744309113004971. Epub 2013 Mar 28. PMID:23545643 doi:http://dx.doi.org/10.1107/S1744309113004971
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