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3v6m

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==Inhibition of caspase-6 activity by single mutation outside the active site==
==Inhibition of caspase-6 activity by single mutation outside the active site==
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<StructureSection load='3v6m' size='340' side='right' caption='[[3v6m]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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<StructureSection load='3v6m' size='340' side='right'caption='[[3v6m]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6M FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v6l|3v6l]], [[3nr2|3nr2]], [[3od5|3od5]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v6l|3v6l]], [[3nr2|3nr2]], [[3od5|3od5]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [http://pdbe.org/3v6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [http://www.ebi.ac.uk/pdbsum/3v6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6m ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [https://pdbe.org/3v6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [https://www.ebi.ac.uk/pdbsum/3v6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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[[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Caspase-6]]
[[Category: Caspase-6]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Cao, Q]]
[[Category: Cao, Q]]
[[Category: Li, L F]]
[[Category: Li, L F]]

Revision as of 08:35, 20 July 2022

Inhibition of caspase-6 activity by single mutation outside the active site

PDB ID 3v6m

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