4lv8

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==Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI==
==Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI==
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<StructureSection load='4lv8' size='340' side='right' caption='[[4lv8]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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<StructureSection load='4lv8' size='340' side='right'caption='[[4lv8]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Toxoplasma_gondii_type_i Toxoplasma gondii type i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LV8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Toxoplasma_gondii_type_I Toxoplasma gondii type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LV8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lv5|4lv5]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv8 OCA], [https://pdbe.org/4lv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4lv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lv8 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ROP5C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1209525 Toxoplasma gondii type I]), Iigp1, Irga6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv8 OCA], [http://pdbe.org/4lv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lv8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
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[https://www.uniprot.org/uniprot/I6ZQR7_TOXGO I6ZQR7_TOXGO]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Toxoplasma gondii type i]]
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[[Category: Mus musculus]]
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[[Category: Boothroyd, J C]]
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[[Category: Toxoplasma gondii type I]]
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[[Category: Reese, M L]]
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[[Category: Boothroyd JC]]
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[[Category: Guanine dissociation inhibitor]]
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[[Category: Reese ML]]
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[[Category: Immune related gtpase]]
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[[Category: Parasite effector]]
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[[Category: Transferase-hydrolase complex]]
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Revision as of 10:33, 21 December 2022

Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI

PDB ID 4lv8

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