1l9a

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[[Image:1l9a.gif|left|200px]]
[[Image:1l9a.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1l9a |SIZE=350|CAPTION= <scene name='initialview01'>1l9a</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1l9a", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CCC:CYTIDINE-5&#39;-PHOSPHATE-2&#39;,3&#39;-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= SRP19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
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|DOMAIN=
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{{STRUCTURE_1l9a| PDB=1l9a | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9a OCA], [http://www.ebi.ac.uk/pdbsum/1l9a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l9a RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA'''
'''CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA'''
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[[Category: Nagai, K.]]
[[Category: Nagai, K.]]
[[Category: Oubridge, C.]]
[[Category: Oubridge, C.]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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[[Category: ribonucleoprotein]]
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[[Category: Ribonucleoprotein]]
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[[Category: signal recognition particle]]
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[[Category: Signal recognition particle]]
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[[Category: srp]]
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[[Category: Srp]]
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[[Category: tetraloop]]
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[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:41:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:59:55 2008''
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Revision as of 20:41, 2 May 2008

Image:1l9a.gif

Template:STRUCTURE 1l9a

CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA


Overview

The signal recognition particle (SRP) is a ribonucleoprotein particle involved in GTP-dependent translocation of secretory proteins across membranes. In Archaea and Eukarya, SRP19 binds to 7SL RNA and promotes the incorporation of SRP54, which contains the binding sites for GTP, the signal peptide, and the membrane-bound SRP receptor. We have determined the crystal structure of Methanococcus jannaschii SRP19 bound to the S domain of human 7SL RNA at 2.9 A resolution. SRP19 clamps the tetraloops of two branched helices (helices 6 and 8) and allows them to interact side by side. Helix 6 acts as a splint for helix 8 and partially preorganizes the binding site for SRP54 in helix 8, thereby facilitating the binding of SRP54 in assembly.

About this Structure

1L9A is a Protein complex structure of sequences from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle., Oubridge C, Kuglstatter A, Jovine L, Nagai K, Mol Cell. 2002 Jun;9(6):1251-61. PMID:12086622 Page seeded by OCA on Fri May 2 23:41:24 2008

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