3oes

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Current revision (09:37, 6 September 2023) (edit) (undo)
 
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==Crystal structure of the small GTPase RhebL1==
==Crystal structure of the small GTPase RhebL1==
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<StructureSection load='3oes' size='340' side='right' caption='[[3oes]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3oes' size='340' side='right'caption='[[3oes]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3oes]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OES FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3oes]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OES FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHEBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oes OCA], [http://pdbe.org/3oes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oes RCSB], [http://www.ebi.ac.uk/pdbsum/3oes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oes ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oes OCA], [https://pdbe.org/3oes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oes RCSB], [https://www.ebi.ac.uk/pdbsum/3oes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oes ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/REBL1_HUMAN REBL1_HUMAN]] Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.<ref>PMID:16328882</ref> <ref>PMID:12869548</ref> <ref>PMID:16098514</ref> <ref>PMID:17162089</ref>
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[https://www.uniprot.org/uniprot/REBL1_HUMAN REBL1_HUMAN] Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.<ref>PMID:16328882</ref> <ref>PMID:12869548</ref> <ref>PMID:16098514</ref> <ref>PMID:17162089</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/3oes_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/3oes_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Loppnau, P]]
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[[Category: Edwards AM]]
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[[Category: Nedyalkova, L]]
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[[Category: Loppnau P]]
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[[Category: Park, H]]
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[[Category: Nedyalkova L]]
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[[Category: Structural genomic]]
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[[Category: Park H]]
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[[Category: Shen, L]]
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[[Category: Shen L]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Tong, Y]]
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[[Category: Tong Y]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Zhong, N]]
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[[Category: Zhong N]]
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[[Category: Hydrolase]]
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[[Category: Sgc]]
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[[Category: Small gtpase]]
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Current revision

Crystal structure of the small GTPase RhebL1

PDB ID 3oes

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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