4ng6
From Proteopedia
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<StructureSection load='4ng6' size='340' side='right' caption='[[4ng6]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='4ng6' size='340' side='right' caption='[[4ng6]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ng6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NG6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4ng6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NG6 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kqs|4kqs]], [[1yq7|1yq7]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kq5|4kq5]], [[4kqs|4kqs]], [[1yq7|1yq7]]</td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ng6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ng6 OCA], [http://pdbe.org/4ng6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ng6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ng6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ng6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ng6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ng6 OCA], [http://pdbe.org/4ng6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ng6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ng6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ng6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Barnett, B L]] | [[Category: Barnett, B L]] | ||
[[Category: Dunford, J E]] | [[Category: Dunford, J E]] | ||
Revision as of 08:13, 22 November 2017
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
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Categories: Human | Barnett, B L | Dunford, J E | Ebetino, F H | Evdokimov, A | Kavanagh, K L | Kwaasi, A A | Muniz, J R.C | Oppermann, U | Pilka, E | Russell, R G.G | Tsoumpra, M K | Walter, R L | Alpha-helical prenyltransferase | Bisphosphonate | Cholesterol synthesis | Isoprene biosynthesis | Isoprenoid pathway | Lipid synthesis | Steroid biosynthesis | Transferase
