3nv0

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==Crystal structure and mutational analysis of the NXF2/NXT1 heterodimeric complex from caenorhabditis elegans at 1.84 A resolution==
==Crystal structure and mutational analysis of the NXF2/NXT1 heterodimeric complex from caenorhabditis elegans at 1.84 A resolution==
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<StructureSection load='3nv0' size='340' side='right' caption='[[3nv0]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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<StructureSection load='3nv0' size='340' side='right'caption='[[3nv0]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NV0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C15H11.6, nxf-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), nxt-1, nxt1, Y71F9AM.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C15H11.6, nxf-2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), nxt-1, nxt1, Y71F9AM.5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv0 OCA], [http://pdbe.org/3nv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nv0 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv0 OCA], [https://pdbe.org/3nv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nv0 RCSB], [https://www.ebi.ac.uk/pdbsum/3nv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NXF2_CAEEL NXF2_CAEEL]] May be involved in the export of cellular mRNA to the cytoplasm (By similarity). [[http://www.uniprot.org/uniprot/NXT1_CAEEL NXT1_CAEEL]] Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).
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[[https://www.uniprot.org/uniprot/NXF2_CAEEL NXF2_CAEEL]] May be involved in the export of cellular mRNA to the cytoplasm (By similarity). [[https://www.uniprot.org/uniprot/NXT1_CAEEL NXT1_CAEEL]] Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Caeel]]
[[Category: Caeel]]
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[[Category: Large Structures]]
[[Category: Carmel, A B]]
[[Category: Carmel, A B]]
[[Category: Kerkow, D E]]
[[Category: Kerkow, D E]]

Revision as of 07:09, 12 May 2022

Crystal structure and mutational analysis of the NXF2/NXT1 heterodimeric complex from caenorhabditis elegans at 1.84 A resolution

PDB ID 3nv0

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