1lc6

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[[Image:1lc6.gif|left|200px]]
[[Image:1lc6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lc6 |SIZE=350|CAPTION= <scene name='initialview01'>1lc6</scene>
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The line below this paragraph, containing "STRUCTURE_1lc6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1lc6| PDB=1lc6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lc6 OCA], [http://www.ebi.ac.uk/pdbsum/1lc6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lc6 RCSB]</span>
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'''Solution Structure of the U6 Intramolecular Stem-loop RNA'''
'''Solution Structure of the U6 Intramolecular Stem-loop RNA'''
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==About this Structure==
==About this Structure==
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1LC6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].
==Reference==
==Reference==
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11992125 11992125]
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11992125 11992125]
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[[Category: Protein complex]]
 
[[Category: Allmann, A M.]]
[[Category: Allmann, A M.]]
[[Category: Brow, D A.]]
[[Category: Brow, D A.]]
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[[Category: Huppler, A.]]
[[Category: Huppler, A.]]
[[Category: Nikstad, L J.]]
[[Category: Nikstad, L J.]]
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[[Category: pentaloop]]
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[[Category: Pentaloop]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: stem-loop]]
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[[Category: Stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:46:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:00:56 2008''
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Revision as of 20:46, 2 May 2008

Image:1lc6.gif

Template:STRUCTURE 1lc6

Solution Structure of the U6 Intramolecular Stem-loop RNA


Overview

U6 RNA is a key component of the catalytic core of the spliceosome. A metal ion essential for the first catalytic step of pre-mRNA splicing binds to the U80 Sp phosphate oxygen within the yeast U6 intramolecular stem-loop (ISL). Here we present the first structural data for U6 RNA, revealing the three-dimensional structure of the highly conserved U6 ISL. The ISL binds metal ion at the U80 site with the same stereo specificity as the intact spliceosome. The metal-binding site is adjacent to a readily protonated C.A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing.

About this Structure

Full crystallographic information is available from OCA.

Reference

Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure., Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE, Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:11992125 Page seeded by OCA on Fri May 2 23:46:49 2008

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