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4cqx

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Revision as of 09:40, 20 March 2019

H5 (tyTy) Del133/Ile155Thr Mutant Haemagglutinin in Complex with Human Receptor Analogue 6'SLN

Structural highlights

4cqx is a 6 chain structure with sequence from Influenza a virus (a/turkey/turkey/1/2005(h5n1)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Related:	4cqp, 4cqq, 4cqr, 4cqs, 4cqt, 4cqu, 4cqv, 4cqw, 4cqy, 4cqz, 4cr0
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[Q207Z6_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

Publication Abstract from PubMed

Mutant H5N1 influenza viruses have been isolated from humans that have increased human receptor avidity. We have compared the receptor binding properties of these mutants with those of wild-type viruses, and determined the structures of their haemagglutinins in complex with receptor analogues. Mutants from Vietnam bind tighter to human receptor by acquiring basic residues near the receptor binding site. They bind more weakly to avian receptor because they lack specific interactions between Asn-186 and Gln-226. In contrast, a double mutant, Delta133/Ile155Thr, isolated in Egypt has greater avidity for human receptor while retaining wild-type avidity for avian receptor. Despite these increases in human receptor binding, none of the mutants prefers human receptor, unlike aerosol transmissible H5N1 viruses. Nevertheless, mutants with high avidity for both human and avian receptors may be intermediates in the evolution of H5N1 viruses that could infect both humans and poultry.

Enhanced human receptor binding by H5 haemagglutinins.,Xiong X, Xiao H, Martin SR, Coombs PJ, Liu J, Collins PJ, Vachieri SG, Walker PA, Lin YP, McCauley JW, Gamblin SJ, Skehel JJ Virology. 2014 May;456-457:179-87. doi: 10.1016/j.virol.2014.03.008. Epub 2014, Apr 12. PMID:24889237^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Xiong X, Xiao H, Martin SR, Coombs PJ, Liu J, Collins PJ, Vachieri SG, Walker PA, Lin YP, McCauley JW, Gamblin SJ, Skehel JJ. Enhanced human receptor binding by H5 haemagglutinins. Virology. 2014 May;456-457:179-87. doi: 10.1016/j.virol.2014.03.008. Epub 2014, Apr 12. PMID:24889237 doi:http://dx.doi.org/10.1016/j.virol.2014.03.008

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cqx"

@@ Line 1: / Line 1: @@
 ==H5 (tyTy) Del133/Ile155Thr Mutant Haemagglutinin in Complex with Human Receptor Analogue 6'SLN==
-<StructureSection load='4cqx' size='340' side='right' caption='[[4cqx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='4cqx' size='340' side='right'caption='[[4cqx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4cqx]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4cqx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/turkey/turkey/1/2005(h5n1)) Influenza a virus (a/turkey/turkey/1/2005(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQX FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqs|4cqs]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqw|4cqw]], [[4cqy|4cqy]], [[4cqz|4cqz]], [[4cr0|4cr0]]</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqx OCA], [http://pdbe.org/4cqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cqx RCSB], [http://www.ebi.ac.uk/pdbsum/4cqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqx ProSAT]</span></td></tr>
@@ Line 27: / Line 26: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Collins, P J]]
 [[Category: Coombs, P J]]

4cqx

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Revision as of 09:40, 20 March 2019

H5 (tyTy) Del133/Ile155Thr Mutant Haemagglutinin in Complex with Human Receptor Analogue 6'SLN

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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