3w6h
From Proteopedia
(Difference between revisions)
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==Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide== | ==Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide== | ||
| - | <StructureSection load='3w6h' size='340' side='right' caption='[[3w6h]], [[Resolution|resolution]] 2.96Å' scene=''> | + | <StructureSection load='3w6h' size='340' side='right'caption='[[3w6h]], [[Resolution|resolution]] 2.96Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3w6h]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3w6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W6H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>, <scene name='pdbligand=FLB:1-(2-ETHOXYETHOXY)-3,5-BIS(TRIFLUOROMETHYL)BENZENE'>FLB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>, <scene name='pdbligand=FLB:1-(2-ETHOXYETHOXY)-3,5-BIS(TRIFLUOROMETHYL)BENZENE'>FLB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w6i|3w6i]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3w6i|3w6i]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CA1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w6h OCA], [https://pdbe.org/3w6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w6h RCSB], [https://www.ebi.ac.uk/pdbsum/3w6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w6h ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN]] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref> |
==See Also== | ==See Also== | ||
| - | *[[Carbonic anhydrase|Carbonic anhydrase]] | + | *[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Carbonate dehydratase]] | [[Category: Carbonate dehydratase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arita, K]] | [[Category: Arita, K]] | ||
[[Category: Ariyoshi, M]] | [[Category: Ariyoshi, M]] | ||
Revision as of 05:24, 3 August 2022
Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide
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Categories: Carbonate dehydratase | Human | Large Structures | Arita, K | Ariyoshi, M | Ashihara, E | Hamachi, I | Kioi, Y | Morito, A | Otani, J | Shirakawa, M | Takaoka, Y | Tochio, H | 19f-nmr | Chemical biology | Lyase | Semisynthetic biosensor
