3p8z

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==Dengue Methyltransferase bound to a SAM-based inhibitor==
==Dengue Methyltransferase bound to a SAM-based inhibitor==
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<StructureSection load='3p8z' size='340' side='right' caption='[[3p8z]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3p8z' size='340' side='right'caption='[[3p8z]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p8z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P8Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p8z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P8Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=36A:(S)-2-AMINO-4-(((2S,3S,4R,5R)-5-(6-(3-CHLOROBENZYLAMINO)-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYLTHIO)BUTANOIC+ACID'>36A</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=36A:(S)-2-AMINO-4-(((2S,3S,4R,5R)-5-(6-(3-CHLOROBENZYLAMINO)-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYLTHIO)BUTANOIC+ACID'>36A</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p97|3p97]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p97|3p97]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8z OCA], [http://pdbe.org/3p8z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p8z RCSB], [http://www.ebi.ac.uk/pdbsum/3p8z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p8z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8z OCA], [https://pdbe.org/3p8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p8z RCSB], [https://www.ebi.ac.uk/pdbsum/3p8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p8z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C1KBQ3_9FLAV C1KBQ3_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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[[https://www.uniprot.org/uniprot/C1KBQ3_9FLAV C1KBQ3_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Nonstructural protein|Nonstructural protein]]
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*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Dengue virus 3]]
[[Category: Dengue virus 3]]
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[[Category: Large Structures]]
[[Category: Lescar, J]]
[[Category: Lescar, J]]
[[Category: Noble, C G]]
[[Category: Noble, C G]]

Revision as of 08:29, 25 May 2022

Dengue Methyltransferase bound to a SAM-based inhibitor

PDB ID 3p8z

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