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3rnq

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==Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2==
==Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2==
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<StructureSection load='3rnq' size='340' side='right' caption='[[3rnq]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='3rnq' size='340' side='right'caption='[[3rnq]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rnq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rnq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNQ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1npu|1npu]], [[3bov|3bov]], [[3bp5|3bp5]], [[3bp6|3bp6]], [[3rnk|3rnk]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1npu|1npu]], [[3bov|3bov]], [[3bp5|3bp5]], [[3bp6|3bp6]], [[3rnk|3rnk]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B7dc, Btdc, Cd273, Murine, Pdcd1lg2, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Pd1, Pdcd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B7dc, Btdc, Cd273, Murine, Pdcd1lg2, Pdl2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Pd1, Pdcd1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnq OCA], [http://pdbe.org/3rnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rnq RCSB], [http://www.ebi.ac.uk/pdbsum/3rnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnq OCA], [https://pdbe.org/3rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnq RCSB], [https://www.ebi.ac.uk/pdbsum/3rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref> [[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
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[[https://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref> [[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
==See Also==
==See Also==
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*[[Cell death protein|Cell death protein]]
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Almo, S C]]
[[Category: Almo, S C]]

Revision as of 10:18, 22 June 2022

Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2

PDB ID 3rnq

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