1lir
From Proteopedia
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'''LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES''' | '''LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES''' | ||
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[[Category: Lu, Z.]] | [[Category: Lu, Z.]] | ||
[[Category: Renisio, J G.]] | [[Category: Renisio, J G.]] | ||
| - | [[Category: | + | [[Category: Inward rectifier potassium channel]] |
| - | [[Category: | + | [[Category: Neurotoxin]] |
| - | [[Category: | + | [[Category: Potassium channel blocker]] |
| - | [[Category: | + | [[Category: Scorpion]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:57:42 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:57, 2 May 2008
LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES
Overview
Lq2 is a unique scorpion toxin. Acting from the extracellular side, Lq2 blocks the ion conduction pore in not only the voltage- and Ca2+ -activated channels, but also the inward-rectifier K+ channels. This finding argues that the three-dimensional structures of the pores in these K+ channels are similar. However, the amino acid sequences that form the external part of the pore are minimally conserved among the various classes of K+ channels. Because Lq2 can bind to all the three classes of K+ channels, we can use Lq2 as a structural probe to examine how the non-conserved pore-forming sequences are arranged in space to form similar pore structures. In the present study, we determined the three-dimensional structure of Lq2 using nuclear magnetic resonance (NMR) techniques. Lq2 consists of an alpha-helix (residues S10 to L20) and a beta-sheet, connected by an alphabeta3 loop (residues N22 to N24). The beta-sheet has two well-defined anti-parallel strands (residues G26 to M29 and residues K32 to C35), which are connected by a type I' beta-turn centered between residues N30 and K31. The N-terminal segment (residues Z1 to T8) appears to form a quasi-third strand of the beta-sheet.
About this Structure
1LIR is a Single protein structure of sequence from Leiurus quinquestriatus hebraeus. Full crystallographic information is available from OCA.
Reference
Solution structure of potassium channel-inhibiting scorpion toxin Lq2., Renisio JG, Lu Z, Blanc E, Jin W, Lewis JH, Bornet O, Darbon H, Proteins. 1999 Mar 1;34(4):417-26. PMID:10081954 Page seeded by OCA on Fri May 2 23:57:42 2008
