2rru
From Proteopedia
(Difference between revisions)
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==Solution structure of the UBA omain of p62 and its interaction with ubiquitin== | ==Solution structure of the UBA omain of p62 and its interaction with ubiquitin== | ||
| - | <StructureSection load='2rru' size='340' side='right' caption='[[2rru]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2rru' size='340' side='right'caption='[[2rru]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2rru]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2rru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRU FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3b0f|3b0f]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b0f|3b0f]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SQSTM1, A170, STAP ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SQSTM1, A170, STAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rru OCA], [https://pdbe.org/2rru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rru RCSB], [https://www.ebi.ac.uk/pdbsum/2rru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rru ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref> |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Arita, K]] | [[Category: Arita, K]] | ||
Revision as of 10:35, 7 July 2021
Solution structure of the UBA omain of p62 and its interaction with ubiquitin
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Categories: Large Structures | Lk3 transgenic mice | Arita, K | Hasegawa, J | Isogai, S | Komatsu, M | Morimoto, D | Shirakawa, M | Sou, Y | Tanaka, K | Tenno, T | Tochio, H | Unzai, S | Autophagy | P62/sqstm1 | Protein binding | Uba domain | Ubiquitin
