1llb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1llb.gif|left|200px]]
[[Image:1llb.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1llb |SIZE=350|CAPTION= <scene name='initialview01'>1llb</scene>, resolution 1.72&Aring;
+
The line below this paragraph, containing "STRUCTURE_1llb", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=PCN:2-{1-[2-(2-AMINO-THIAZOL-4-YL)-2-METHOXYIMINO-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC+ACID'>PCN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ampC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1llb| PDB=1llb | SCENE= }}
-
|RELATEDENTRY=[[1ke4|1KE4]], [[1iel|1IEL]], [[1iem|1IEM]], [[1fcn|1FCN]], [[1kvm|1KVM]], [[1fr6|1FR6]], [[1ll9|1LL9]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1llb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1llb OCA], [http://www.ebi.ac.uk/pdbsum/1llb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1llb RCSB]</span>
+
-
}}
+
'''Crystal Structure Of AmpC beta-Lactamase From E. Coli In Complex With ATMO-penicillin'''
'''Crystal Structure Of AmpC beta-Lactamase From E. Coli In Complex With ATMO-penicillin'''
Line 30: Line 27:
[[Category: Shoichet, B K.]]
[[Category: Shoichet, B K.]]
[[Category: Trehan, I.]]
[[Category: Trehan, I.]]
-
[[Category: beta-lactamase]]
+
[[Category: Beta-lactamase]]
-
[[Category: cephalosporinase]]
+
[[Category: Cephalosporinase]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: serine]]
+
[[Category: Serine]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:02:04 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:04:13 2008''
+

Revision as of 21:02, 2 May 2008

Image:1llb.gif

Template:STRUCTURE 1llb

Crystal Structure Of AmpC beta-Lactamase From E. Coli In Complex With ATMO-penicillin


Overview

beta-lactamases confer resistance to beta-lactam antibiotics such as penicillins and cephalosporins. However, beta-lactams that form an acyl-intermediate with the enzyme but subsequently are hindered from forming a catalytically competent conformation seem to be inhibitors of beta-lactamases. This inhibition may be imparted by specific groups on the ubiquitous R(1) side chain of beta-lactams, such as the 2-amino-4-thiazolyl methoxyimino (ATMO) group common among third-generation cephalosporins. Using steric hindrance of deacylation as a design guide, penicillin and carbacephem substrates were converted into effective beta-lactamase inhibitors and antiresistance antibiotics. To investigate the structural bases of inhibition, the crystal structures of the acyl-adducts of the penicillin substrate amoxicillin and the new analogous inhibitor ATMO-penicillin were determined. ATMO-penicillin binds in a catalytically incompetent conformation resembling that adopted by third-generation cephalosporins, demonstrating the transferability of such sterically hindered groups in inhibitor design.

About this Structure

1LLB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Using steric hindrance to design new inhibitors of class C beta-lactamases., Trehan I, Morandi F, Blaszczak LC, Shoichet BK, Chem Biol. 2002 Sep;9(9):971-80. PMID:12323371 Page seeded by OCA on Sat May 3 00:02:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1llb"
Personal tools