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3q0s

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==Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with erk2 NRE==
==Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with erk2 NRE==
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<StructureSection load='3q0s' size='340' side='right' caption='[[3q0s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3q0s' size='340' side='right'caption='[[3q0s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q0s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q0S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0S FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q0l|3q0l]], [[3q0m|3q0m]], [[3q0n|3q0n]], [[3q0o|3q0o]], [[3q0p|3q0p]], [[3q0q|3q0q]], [[3q0r|3q0r]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q0l|3q0l]], [[3q0m|3q0m]], [[3q0n|3q0n]], [[3q0o|3q0o]], [[3q0p|3q0p]], [[3q0q|3q0q]], [[3q0r|3q0r]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PUM2, KIAA0235, PUMH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PUM2, KIAA0235, PUMH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0s OCA], [http://pdbe.org/3q0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q0s RCSB], [http://www.ebi.ac.uk/pdbsum/3q0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0s OCA], [https://pdbe.org/3q0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0s RCSB], [https://www.ebi.ac.uk/pdbsum/3q0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PUM2_HUMAN PUM2_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
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[[https://www.uniprot.org/uniprot/PUM2_HUMAN PUM2_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Hall, T M.T]]
[[Category: Hall, T M.T]]
[[Category: Lu, G]]
[[Category: Lu, G]]

Revision as of 09:05, 25 May 2022

Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with erk2 NRE

PDB ID 3q0s

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