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4oty

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==Crystal structure of lumiracoxib bound to the apo-mouse-cyclooxygenase-2==
==Crystal structure of lumiracoxib bound to the apo-mouse-cyclooxygenase-2==
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<StructureSection load='4oty' size='340' side='right' caption='[[4oty]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='4oty' size='340' side='right'caption='[[4oty]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oty]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4llz 4llz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OTY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4llz 4llz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OTY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oty OCA], [https://pdbe.org/4oty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oty RCSB], [https://www.ebi.ac.uk/pdbsum/4oty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oty ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oty OCA], [http://pdbe.org/4oty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oty RCSB], [http://www.ebi.ac.uk/pdbsum/4oty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oty ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
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[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4oty" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4oty" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Mus musculus]]
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[[Category: Banerjee, S]]
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[[Category: Banerjee S]]
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[[Category: Marnett, L J]]
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[[Category: Marnett LJ]]
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[[Category: Windsor, M A]]
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[[Category: Windsor MA]]
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[[Category: Xu, S]]
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[[Category: Xu S]]
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[[Category: Drug complex]]
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[[Category: Glycosylation]]
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[[Category: Heme]]
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[[Category: Monotopic membrane protein]]
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[[Category: Nsaid]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Protein-drug complex]]
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Revision as of 07:45, 25 January 2023

Crystal structure of lumiracoxib bound to the apo-mouse-cyclooxygenase-2

PDB ID 4oty

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