1lor

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[[Image:1lor.jpg|left|200px]]
[[Image:1lor.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lor |SIZE=350|CAPTION= <scene name='initialview01'>1lor</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1lor", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMP:6-HYDROXYURIDINE-5&#39;-PHOSPHATE'>BMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1lor| PDB=1lor | SCENE= }}
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|RELATEDENTRY=[[1lol|1LOL]], [[1loq|1LOQ]], [[1los|1LOS]], [[1lp6|1LP6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lor OCA], [http://www.ebi.ac.uk/pdbsum/1lor PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lor RCSB]</span>
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}}
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'''crystal structure of orotidine 5'-monophosphate complexed with BMP'''
'''crystal structure of orotidine 5'-monophosphate complexed with BMP'''
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[[Category: Pai, E F.]]
[[Category: Pai, E F.]]
[[Category: Wu, N.]]
[[Category: Wu, N.]]
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[[Category: tim barrel]]
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[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:07:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:05:30 2008''
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Revision as of 21:07, 2 May 2008

Image:1lor.jpg

Template:STRUCTURE 1lor

crystal structure of orotidine 5'-monophosphate complexed with BMP


Overview

The crystal structures of the enzyme orotidine-5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with its product UMP and the inhibitors 6-hydroxyuridine 5'-phosphate (BMP), XMP, and CMP are reported. A mutant version of the protein, in which four residues of the flexible phosphate-binding loop (180)Gly-Gly(190) were removed and Arg(203) was replaced by alanine, was also analyzed. The XMP and CMP complexes reveal a ligand-binding mode that is distinct from the one identified previously with the aromatic rings located outside the binding pocket. A potential pathway for ligand binding is discussed.

About this Structure

1LOR is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase., Wu N, Pai EF, J Biol Chem. 2002 Aug 2;277(31):28080-7. Epub 2002 May 13. PMID:12011084 Page seeded by OCA on Sat May 3 00:07:38 2008

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