This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3ai8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Cathepsin B in complex with the nitroxoline== | ==Cathepsin B in complex with the nitroxoline== | ||
| - | <StructureSection load='3ai8' size='340' side='right' caption='[[3ai8]], [[Resolution|resolution]] 2.11Å' scene=''> | + | <StructureSection load='3ai8' size='340' side='right'caption='[[3ai8]], [[Resolution|resolution]] 2.11Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ai8]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ai8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AI8 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HNQ:5-NITROQUINOLIN-8-OL'>HNQ</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNQ:5-NITROQUINOLIN-8-OL'>HNQ</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSB ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ai8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ai8 OCA], [https://pdbe.org/3ai8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ai8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ai8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ai8 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. |
==See Also== | ==See Also== | ||
*[[Cathepsin|Cathepsin]] | *[[Cathepsin|Cathepsin]] | ||
| + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Cathepsin B]] | [[Category: Cathepsin B]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gobec, S]] | [[Category: Gobec, S]] | ||
[[Category: Kos, J]] | [[Category: Kos, J]] | ||
Revision as of 14:53, 29 December 2021
Cathepsin B in complex with the nitroxoline
| |||||||||||
