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1lq8

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[[Image:1lq8.gif|left|200px]]
[[Image:1lq8.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1lq8", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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{{STRUCTURE_1lq8| PDB=1lq8 | SCENE= }}
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|RELATEDENTRY=[[1ezx|1EZX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lq8 OCA], [http://www.ebi.ac.uk/pdbsum/1lq8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lq8 RCSB]</span>
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'''Crystal structure of cleaved protein C inhibitor'''
'''Crystal structure of cleaved protein C inhibitor'''
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[[Category: Kjellberg, M.]]
[[Category: Kjellberg, M.]]
[[Category: Stenflo, J.]]
[[Category: Stenflo, J.]]
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[[Category: heparin]]
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[[Category: Heparin]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: protein c]]
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[[Category: Protein c]]
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[[Category: retinoic acid]]
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[[Category: Retinoic acid]]
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[[Category: serpin]]
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[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:10:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:05:58 2008''
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Revision as of 21:10, 2 May 2008

Image:1lq8.gif

Template:STRUCTURE 1lq8

Crystal structure of cleaved protein C inhibitor


Overview

Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In blood it acts as a procoagulant, and, in the seminal vesicles, it is required for spermatogenesis. The activity of PCI is affected by heparin binding in a manner unique among the heparin binding serpins, and, in addition, PCI binds hydrophobic hormones with apparent specificity for retinoids. Here we present the 2.4 A crystallographic structure of reactive center loop (RCL) cleaved PCI. A striking feature of the structure is a two-turn N-terminal shortening of helix A, which creates a large hydrophobic pocket that docking studies indicate to be the retinoid binding site. On the basis of surface electrostatic properties, a novel mechanism for heparin activation is proposed.

About this Structure

1LQ8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation., Huntington JA, Kjellberg M, Stenflo J, Structure. 2003 Feb;11(2):205-15. PMID:12575940 Page seeded by OCA on Sat May 3 00:10:07 2008

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