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1lrh

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[[Image:1lrh.gif|left|200px]]
[[Image:1lrh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lrh |SIZE=350|CAPTION= <scene name='initialview01'>1lrh</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1lrh", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NLA:NAPHTHALEN-1-YL-ACETIC+ACID'>NLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|GENE= ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4577 Zea mays])
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|DOMAIN=
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{{STRUCTURE_1lrh| PDB=1lrh | SCENE= }}
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|RELATEDENTRY=[[1lr5|1LR5]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lrh OCA], [http://www.ebi.ac.uk/pdbsum/1lrh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lrh RCSB]</span>
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}}
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'''Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid'''
'''Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid'''
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[[Category: Venis, M.]]
[[Category: Venis, M.]]
[[Category: Woo, E J.]]
[[Category: Woo, E J.]]
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[[Category: beta jellyroll]]
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[[Category: Beta jellyroll]]
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[[Category: double stranded parallel beta helix]]
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[[Category: Double stranded parallel beta helix]]
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[[Category: germin like protein]]
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[[Category: Germin like protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:12:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:06:23 2008''
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Revision as of 21:12, 2 May 2008

Template:STRUCTURE 1lrh

Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid


Overview

The structure of auxin-binding protein 1 (ABP1) from maize has been determined at 1.9 A resolution, revealing its auxin-binding site. The structure confirms that ABP1 belongs to the ancient and functionally diverse germin/seed storage 7S protein superfamily. The binding pocket of ABP1 is predominantly hydrophobic with a metal ion deep inside the pocket coordinated by three histidines and a glutamate. Auxin binds within this pocket, with its carboxylate binding the zinc and its aromatic ring binding hydrophobic residues including Trp151. There is a single disulfide between Cys2 and Cys155. No conformational rearrangement of ABP1 was observed when auxin bound to the protein in the crystal, but examination of the structure reveals a possible mechanism of signal transduction.

About this Structure

1LRH is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.

Reference

Crystal structure of auxin-binding protein 1 in complex with auxin., Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW, EMBO J. 2002 Jun 17;21(12):2877-85. PMID:12065401 Page seeded by OCA on Sat May 3 00:12:42 2008

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