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4do3

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==Structure of FAAH with a non-steroidal anti-inflammatory drug==
==Structure of FAAH with a non-steroidal anti-inflammatory drug==
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<StructureSection load='4do3' size='340' side='right' caption='[[4do3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='4do3' size='340' side='right'caption='[[4do3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4do3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DO3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DO3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4do3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DO3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LA:(2S)-2-(6-CHLORO-9H-CARBAZOL-2-YL)PROPANOIC+ACID'>0LA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OHO:CYCLOHEXANE+AMINOCARBOXYLIC+ACID'>OHO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LA:(2S)-2-(6-CHLORO-9H-CARBAZOL-2-YL)PROPANOIC+ACID'>0LA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OHO:CYCLOHEXANE+AMINOCARBOXYLIC+ACID'>OHO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lj7|3lj7]], [[2vya|2vya]], [[1m5t|1m5t]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4do3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4do3 OCA], [https://pdbe.org/4do3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4do3 RCSB], [https://www.ebi.ac.uk/pdbsum/4do3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4do3 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4do3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4do3 OCA], [http://pdbe.org/4do3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4do3 RCSB], [http://www.ebi.ac.uk/pdbsum/4do3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4do3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
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[[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Fatty acid amide hydrolase]]
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[[Category: Rattus norvegicus]]
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[[Category: Garau, G]]
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[[Category: Garau G]]
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[[Category: Amidase]]
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[[Category: Anandamide]]
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[[Category: Cox]]
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[[Category: Drug]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inflammation]]
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[[Category: Inhibitor]]
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[[Category: Nsaid]]
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[[Category: Pain]]
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Revision as of 08:31, 21 September 2022

Structure of FAAH with a non-steroidal anti-inflammatory drug

PDB ID 4do3

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