1lt8

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[[Image:1lt8.jpg|left|200px]]
[[Image:1lt8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lt8 |SIZE=350|CAPTION= <scene name='initialview01'>1lt8</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1lt8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CBH:S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE'>CBH</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine--homocysteine_S-methyltransferase Betaine--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.5 2.1.1.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1lt8| PDB=1lt8 | SCENE= }}
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|RELATEDENTRY=[[1lt7|1LT7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lt8 OCA], [http://www.ebi.ac.uk/pdbsum/1lt8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lt8 RCSB]</span>
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}}
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'''Reduced Homo sapiens Betaine-Homocysteine S-Methyltransferase in Complex with S-(delta-carboxybutyl)-L-Homocysteine'''
'''Reduced Homo sapiens Betaine-Homocysteine S-Methyltransferase in Complex with S-(delta-carboxybutyl)-L-Homocysteine'''
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[[Category: Ludwig, M L.]]
[[Category: Ludwig, M L.]]
[[Category: Millian, N S.]]
[[Category: Millian, N S.]]
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[[Category: homocysteine metabolism]]
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[[Category: Homocysteine metabolism]]
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[[Category: homocysteinemia]]
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[[Category: Homocysteinemia]]
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[[Category: thiol alkyl transfer]]
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[[Category: Thiol alkyl transfer]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:15:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:05 2008''
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Revision as of 21:15, 2 May 2008

Image:1lt8.jpg

Template:STRUCTURE 1lt8

Reduced Homo sapiens Betaine-Homocysteine S-Methyltransferase in Complex with S-(delta-carboxybutyl)-L-Homocysteine


Overview

Betaine-homocysteine methyl transferase (BHMT) catalyzes the synthesis of methionine from betaine and homocysteine (Hcy), utilizing a zinc ion to activate Hcy. BHMT is a key liver enzyme that is important for homocysteine homeostasis. X-ray structures of human BHMT in its oxidized (Zn-free) and reduced (Zn-replete) forms, the latter in complex with the bisubstrate analog, S(delta-carboxybutyl)-L-homocysteine, were determined at resolutions of 2.15 A and 2.05 A. BHMT is a (beta/alpha)(8) barrel that is distorted to construct the substrate and metal binding sites. The zinc binding sequences G-V/L-N-C and G-G-C-C are at the C termini of strands beta6 and beta8. Oxidation to the Cys217-Cys299 disulfide and expulsion of Zn are accompanied by local rearrangements. The structures identify Hcy binding fingerprints and provide a prototype for the homocysteine S-methyltransferase family.

About this Structure

1LT8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Betaine-homocysteine methyltransferase: zinc in a distorted barrel., Evans JC, Huddler DP, Jiracek J, Castro C, Millian NS, Garrow TA, Ludwig ML, Structure. 2002 Sep;10(9):1159-71. PMID:12220488 Page seeded by OCA on Sat May 3 00:15:53 2008

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