1lti

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[[Image:1lti.jpg|left|200px]]
[[Image:1lti.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lti |SIZE=350|CAPTION= <scene name='initialview01'>1lti</scene>, resolution 2.13&Aring;
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The line below this paragraph, containing "STRUCTURE_1lti", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1lti| PDB=1lti | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB]</span>
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}}
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'''HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN'''
'''HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN'''
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[[Category: Akker, F Van Den.]]
[[Category: Akker, F Van Den.]]
[[Category: Hol, W G.J.]]
[[Category: Hol, W G.J.]]
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[[Category: adp-ribosyl transferase]]
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[[Category: Adp-ribosyl transferase]]
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[[Category: enterotoxin]]
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[[Category: Enterotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:16:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:08 2008''
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Revision as of 21:16, 2 May 2008

Image:1lti.jpg

Template:STRUCTURE 1lti

HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN


Overview

Heat-labile enterotoxin (LT) is part of the cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves to recognize the oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich (T-antigen) tumor marker. The toxin:carbohydrate complex is determined to 2.13 A resolution, yielding an R-factor of 18.5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr, is present in more than 85% of human carcinomas and monitoring its autoimmune response is used for the early detection of tumors. Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T-antigen directed anticancer drug delivery system.

About this Structure

1LTI is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli., van den Akker F, Steensma E, Hol WG, Protein Sci. 1996 Jun;5(6):1184-8. PMID:8762150 Page seeded by OCA on Sat May 3 00:16:23 2008

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