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3ubt

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==Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA==
==Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA==
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<StructureSection load='3ubt' size='340' side='right' caption='[[3ubt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3ubt' size='340' side='right'caption='[[3ubt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ubt]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aegyptius"_trevisan_1889 "bacillus aegyptius" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UBT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ubt]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aegyptius"_trevisan_1889 "bacillus aegyptius" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UBT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">haeIIIM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197575 "Bacillus aegyptius" Trevisan 1889])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">haeIIIM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197575 "Bacillus aegyptius" Trevisan 1889])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ubt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ubt OCA], [http://pdbe.org/3ubt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ubt RCSB], [http://www.ebi.ac.uk/pdbsum/3ubt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ubt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ubt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ubt OCA], [https://pdbe.org/3ubt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ubt RCSB], [https://www.ebi.ac.uk/pdbsum/3ubt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ubt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTH3_HAEAE MTH3_HAEAE]] This methylase recognizes the double-stranded sequence GGCC, causes specific methylation on C-3 on both strands, and protects the DNA from cleavage by the HaeIII endonuclease.
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[[https://www.uniprot.org/uniprot/MTH3_HAEAE MTH3_HAEAE]] This methylase recognizes the double-stranded sequence GGCC, causes specific methylation on C-3 on both strands, and protects the DNA from cleavage by the HaeIII endonuclease.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Bacillus aegyptius trevisan 1889]]
[[Category: Bacillus aegyptius trevisan 1889]]
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[[Category: Large Structures]]
[[Category: Didovyk, A]]
[[Category: Didovyk, A]]
[[Category: Verdine, G L]]
[[Category: Verdine, G L]]

Revision as of 06:06, 13 July 2022

Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA

PDB ID 3ubt

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